Principles of a New Protocol for Prediction of Azole Resistance in Candida albicans Infections on the Basis of ERG11 Polymorphisms
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15 صفحه اولContribution of clinically derived mutations in ERG11 to azole resistance in Candida albicans.
In Candida albicans, the ERG11 gene encodes lanosterol demethylase, the target of the azole antifungals. Mutations in ERG11 that result in an amino acid substitution alter the abilities of the azoles to bind to and inhibit Erg11, resulting in resistance. Although ERG11 mutations have been observed in clinical isolates, the specific contributions of individual ERG11 mutations to azole resistance...
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ژورنال
عنوان ژورنال: Current Microbiology
سال: 2016
ISSN: 0343-8651,1432-0991
DOI: 10.1007/s00284-016-1039-3